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JABSOM Tropical Medicine Seminar

TRMD 690 Zoom Link: https://zoom.us/j/97962975142?pwd=aFdJZmhrbjdDOGQ2UFZHZTYyeDhUZz09 Call in: (669) 900-6833 Zoom ID: 979 6297 5142 Passcode: 306033*** "African Trypanosomes and the Human Blood-Brain Barrier: Insights and Revelations and with a bonus side-track to dengue"*** Human African trypanosomiasis (HAT; commonly called sleeping sickness) is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan countries. Sleeping sickness is caused by two subspecies of African trypanosome, Trypanosoma brucei rhodesiense and T. b. gambiense causing East African and West African sleeping sickness, respectively. In classical late stage human sleeping sickness the parasites invade the central nervous system and the infected individuals suffer from progressive neurologic involvement with concomitant psychiatric disorders and, if untreated, death. In this talk, I review our progress to delineate the mechanism of African trypanosome traversal across the human BBB at the molecular and cellular levels with the hope that this research that will lead to better therapies against the disease caused by this deadly parasite. I will also side-track to a novel dengue therapeutic idea for severe dengue.*** Speaker: Dennis J. Grab, Ph.D., Professor, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland

Event Sponsor
JABSOM Tropical Medicine, Mānoa Campus

More Information
Vivek Nerurkar, Ph.D., 808-692-1668, nerurkar@hawaii.edu, TRMD 690_Dennis Grab (PDF)